Cutaneous Lymphoma:
Diagnosis and Treatment
For Cutaneous Lymphoma: Diagnosis and Treatment, Drs. John C. Hall and Brian J. Hall have assembled leaders on the topic of cutaneous lymphoma. The text discusses the new classifications of cutaneous lymphoma. Its epidemiology is then reviewed.
A general approach to the patient suspected of having a cutaneous lymphoma is outlined. Discussion of diagnosis, histopathology, molecular genetics, and treatment of each subgroup is presented. Precursors and mimics, which make this such a fascinating group of diseases, are reviewed. Systemic considerations of this primarily cutaneous disease are also covered. Molecular genetics of cutaneous T-cell lymphomas that have helped advance all of medicine are discussed, and finally, the future of this dynamic area of medicine is detailed.
Chapter 1
Cutaneous Lymphoma: Definition, Classification, and Staging
Introduction
Cutaneous T-cell lymphoma
Primary cutaneous peripheral T-cell lymphoma, unspecified
Primary cutaneous B-cell lymphoma
Blastic plasmacytoid dendritic cell neoplasm
Staging of cutaneous T-cell lymphoma
Summary
Suggested readings
Chapter 2
Cutaneous Lymphoma: Epidemiology
Epidemiology
Incidence
Etiology
Risk factors
Mortality and survival
Acknowledgment
Suggested readings
Chapter 3
Approach and Assessment for a Patient with Suspected Cutaneous Lymphoma
Suggested readings
Chapter 4
Approach and Assessment of Skin Biopsy for a Patient With Suspected Cutaneous Lymphoma
Introduction
Histopathology
Immunohistochemistry
Gene rearrangement
Conclusion
Suggested readings
Chapter 5
Mycosis Fungoides (Cutaneous T-Cell Lymphoma)
Setting the stage and history
Pathogenesis
Genetics
The malignant T-cell/skin-homing T-cells
Epidemiology
Clinical findings
Histology
Staging
Prognosis
Treatment
Associations
Suggested readings
Chapter 6
Mycosis Fungoides Variants
Background
Etiology and pathogenesis
Epidemiology
Classic mycosis fungoides
Hypopigmented mycosis fungoides
Pagetoid reticulosis
Granulomatous slack skin
Follicular mycosis fungoides
Syringotropic mycosis fungoides
Poikilodermatous mycosis fungoides
Pigmented purpuric mycosis fungoides
Palmar-plantar mycosis fungoides
Summary
Suggested readings
Chapter 7
Sézary Syndrome
Introduction
Epidemiology
A diagnosis in evolution
Pathogenesis and immunology
Clinical evaluation of a patient
Clinical findings
Histopathologic findings
Methods of assessing hematologic involvement
Differential diagnosis
Treatment
Conclusion
Suggested readings
Chapter 8
Adult T-Cell Leukemia/Lymphoma
Introduction
Epidemiology
Development of adult T-cell leukemia/lymphoma
Diagnosis
Classification/prognosis
Treatment
Conclusions
Suggested readings
Chapter 9
CD30+ Lymphoproliferative Disorders
The CD30 antigen
Lymphomatoid papulosis
Primary cutaneous anaplastic large cell lymphoma
Other lymphoproliferative disorders with CD30+ expression
Reactive conditions with CD30+ lymphocytes (CD30+ pseudolymphomas)
Suggested readings
Chapter 10
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Background
Etiology/pathogenesis
Epidemiology
Clinical findings
Histopathologic findings
Cytogenetics/molecular
Treatment
Summary
Suggested readings
Chapter 11
Cutaneous Extranodal Natural Killer/T-Cell Lymphoma
Background
Etiology/pathogenesis
Epidemiology
Clinical findings
Histopathologic findings
Cytogenetic/molecular aspects
Treatment
Summary
Suggested readings
Chapter 12
Primary Cutaneous Peripheral T-Cell Lymphoma, Unspecified
Primary cutaneous aggressive epidermotropic CD8+ cytotoxic T-cell lymphoma
Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma
Cutaneous γ/δ T-cell lymphoma
Primary cutaneous peripheral T-cell lymphoma, unspecified
Suggested readings
Chapter 13
Cutaneous B-Cell Lymphomas
Primary cutaneous follicle center lymphoma
Primary cutaneous marginal zone B-cell lymphoma (PCMZL)
Primary cutaneous large B-cell lymphoma, leg-type
Other primary cutaneous large B-cell lymphomas
Suggested readings
Chapter 14
Skin Conditions Considered to be Precursors to Cutaneous Lymphoma
Introduction
Precursors to cutaneous T-cell lymphoma
Precursors to cutaneous B-cell lymphoma
Conclusions
Suggested readings
Chapter 15
Clinical Mimics of Cutaneous Lymphoma
Introduction
B-cell–rich pseudolymphomas
T-cell–rich pseudolymphomas
Mixed cell type, lymphocyte-rich pseudolymphoma
Lymphocyte-poor pseudolymphoma
Neutrophil-rich pseudolymphomas
Miscellaneous benign dermatoses acting as pseudolymphomas
Malignant disorders acting as pseudolymphoma
Selected morphologies with lymphoma in the differential diagnosis
Suggested readings
Chapter 16
Histopathologic Mimics of Cutaneous Lymphoma
Introduction
Conditions that may histopathologically simulate cutaneous lymphoma
Suggested readings
Chapter 17
Systemic Involvement and Evaluation of Cutaneous T-Cell Lymphoma
Introduction
Staging and prognosis of mycosis fungoides/Sézary’s syndrome
Systemic therapy for advanced mycosis fungoides/Sézary’s syndrome
Autologous and allogeneic bone marrow transplantation
Suggested readings
Chapter 18
Molecular Genetics of Cutaneous Lymphomas
Introduction
Cutaneous B-cell lymphomas
Cutaneous T-cell lymphomas
Summary
Suggested readings
Chapter 19
Future Strategies in Diagnosis and Treatment of Cutaneous Lymphomas
Diagnosis
Treatment
Conclusions
Suggested readings
INDEX