Molecular Imaging: Principles and Practice

Ralph Weissleder, MD PhD

Professor of Radiology and Systems Biology
Harvard Medical School
Director, Center for Systems Biology
Massachusetts General Hospital
Boston, Massachusetts

Brian D. Ross, PhD

Professor of Radiology and Biological Chemistry
Co-Director Center for Molecular Imaging
University of Michigan Medical School
Ann Arbor, Michigan

Alnawaz Rehemtulla, PhD

Ruth Tuttle Freeman Research Professor
Department of Radiation Oncology and Radiology
Co-Director Center for Molecular Imaging
University of Michigan Medical School
Ann Arbor, Michigan

Sanjiv Sam Gambhir, MD PhD

Virginia & D.K. Ludwig Professor of Radiology and Bioengineering
Director, Molecular Imaging Program at Stanford (MIPS)
Director, Canary Center at Stanford for Cancer Early Detection
Chief, Division of Nuclear Medicine
Stanford University School of Medicine
Stanford, California

In the 21st century, the field of molecular imaging of living subjects has evolved considerably and has seen spectacular advances in chemistry, engineering, and biomedical applications. Comprehensive molecular imaging centers have been established in the US, Europe, and Asia and are increasingly integrated into basic sciences and translational networks.

New investigators, collaborators, and students drawn into this multidisciplinary field have often expressed the desire and need for an authoritative textbook. The editors designed Molecular Imaging: Principles and Practice precisely to fill the need for an authoritative, effective resource with contributions from 160 leading authors.

Given the multidisciplinary nature of the field, the information is organized into six logical, illustrated sections. See the Table of Contents tab below for section and chapter titles.

Molecular Imaging: Principles and Practice received a 97 Doody’s Review score.

Part I: Molecular Imaging Technologies

Chapter 1    General Principles of Molecular Imaging
Chapter 2    Imaging of Structure and Function with PET/CT
Chapter 3    PET/MRI
Chapter 4    SPECT and SPECT/CT
Chapter 5    Principles of Micro X-ray Computed Tomography
Chapter 6    Small Animal SPECT, SPECT/CT, and SPECT/MRI
Chapter 7    Instrumentation and Methods to Combine Small Animal PET with Other Imaging Modalities
Chapter 8    Functional Imaging Using Bioluminescent Imaging
Chapter 9    Optical Multimodality Technologies
Chapter 10    Fiber Optic Fluorescence Imaging
Chapter 11    Fluorescence Tomography
Chapter 12    Endomicroscopy
Chapter 13    Intravital Microscopy
Chapter 14    Diffuse Optical Tomography and Spectroscopy
Chapter 15    Ultrasound
Chapter 16    Molecular Photoacoustic Tomography
Chapter 17    Optical Projection Tomography
Chapter 18    Potential Roles for Retrospective Registration in Molecular Imaging

Part II: Chemistry of Molecular Imaging

Chapter 19    Chemistry of Molecular Imaging: An Overview
Chapter 20    Radiochemistry of PET
Chapter 21    Radiochemistry of SPECT: Examples of 99MTc and 111In Complexes
Chapter 22    Nanochemistry for Molecular Imaging
Chapter 23    Newer Bioconjugation Methods
Chapter 24    Targeted Antibodies and Peptides
Chapter 25    Hyperpolarized 13C Magnetic Resonance Imaging – Principles and Applications
Chapter 26    Magnetic Resonance Imaging Agents
Chapter 27    Optical Imaging Agents
Chapter 28    Ultrasound Contrast Agents
Chapter 29    Multimodality Agents
Chapter 30    “Click Chemistry”: Applications to Molecular Imaging
Chapter 31    The “One-Bead-One-Compound” Combinatorial Approach to Identifying Molecular Imaging Probes
Chapter 32    Chemical Biology Approaches to Molecular Imaging
Chapter 33    Theranostics:  Agents for Diagnosis and Therapy
Chapter 34    Magnetic Nanoparticles
Chapter 35    Fluorocarbon Agents for Quantitative Multimodal Molecular Imaging and Targeted Therapeutics
Chapter 36    Aptamers for Molecular Imaging
Chapter 37    Nonclinical Product Developmental Strategies, Safety Considerations, and Toxicity Profiles of Medical Imaging and Radiopharmaceutical Products

Part III: Molecular Imaging in Cell & Molecular Biology

Chapter 38    Overview of Molecular and Cell Biology
Chapter 39    Systems Biology
Chapter 40    Protein Engineering for Molecular Imaging
Chapter 41    Phage Display for Imaging Agent Development
Chapter 42    Molecular Imaging of Gene Therapy
Chapter 43    Developing Diagnostic and Therapeutic Viral Vectors
Chapter 44    Cell Voyeurism Using Magnetic Resonance Imaging
Chapter 45    Tumor Vasculature
Chapter 46    Imaging Hypoxia
Chapter 47    Molecular Imaging of Protein-Protein Interactions
Chapter 48    Fluorescence Readouts of Biochemistry in Live Cells and Organisms
Chapter 49    Imaging of Signaling Pathways

Part IV: Applications of Molecular Imaging

Oncology:
Chapter 50    Molecular and Functional Imaging of the Tumor Microenvironment
Chapter 51    Novel MR and PET Imaging in the RT Planning and Assessment of Response of Malignant Gliomas
Chapter 52    PET Diagnosis and Response Monitoring in Oncology
Chapter 53    Magnetic Resonance Spectroscopy Treatment Response and Detection
Chapter 54    Diffusion MRI: A Biomarker for Early Cancer Treatment Response Assessment

Cardiovascular:
Chapter 55    Myocardial Metabolism
Chapter 56    Congestive Heart Failure
Chapter 57    Molecular Imaging of Atherosclerosis
Chapter 58    Thrombosis and Embolism
Chapter 59    Molecular Imaging of Stem Cells in Myocardial Infarction

CNS:
Chapter 60    Central Nervous System Molecular Imaging
Chapter 61    Neuroreceptor Imaging: Applications, Advances, and Limitations
Chapter 62    PET and SPET Imaging of Neurodegenerative Diseases

Autoimmune/Immunology:
Chapter 63    Molecular Imaging of Autoimmune Diseases
Chapter 64    Rheumatoid Arthritis
Chapter 65    Autoimmune Diabetes
Chapter 66    Imaging in Asthma

Part V: Molecular Imaging in Drug Evaluation

Chapter 67    Molecular and Functional Imaging in Drug Development
Chapter 68    PET Imaging Cancer Clinical Trials
Chapter 69    MR Imaging in Clinical Trials
Chapter 70    Imaging of Gene Therapy: Basis and Clinical Trials

Part VI: Other

Chapter 71    Visualization
Chapter 72    Quantification of Radiotracer Uptake into Tissue
Chapter 73    Mining Genomic Data for Molecular Imaging Targets
Chapter 74    Pharmacokinetic Modeling
Chapter 75    Cost-Effectiveness Analysis/Economics of Probe Development
Chapter 76    Regulatory and Reimbursement Process for Imaging Agents and Devices

Index

$189.00 Add To Cart
Book Details

1380 Pages

Format

Hardback
8.5 in. x 11 in.

Publication Date June 2010
Audience

Radiologists, biomedical researchers, students

ISBN 9781607950059
Errata Notice

Erratum: pp. 425-443